Top 16 Anti-Malware APIs for Developers in 2026: Complete Security Integration Guide

async function scanFileWithVirusTotal(file) {
  const API_KEY = process.env.VIRUSTOTAL_API_KEY;
  const formData = new FormData();
  formData.append('file', file);

  // Submit file for scanning
  const uploadResponse = await fetch('https://www.virustotal.com/api/v3/files', {
    method: 'POST',
    headers: { 'x-apikey': API_KEY },
    body: formData
  });
  
  const uploadData = await uploadResponse.json();
  const analysisId = uploadData.data.id;
  
  // Poll for results
  let analysisComplete = false;
  let results;
  
  while (!analysisComplete) {
    await new Promise(resolve => setTimeout(resolve, 5000)); // Wait 5 seconds
    
    const resultsResponse = await fetch(
      `https://www.virustotal.com/api/v3/analyses/${analysisId}`,
      { headers: { 'x-apikey': API_KEY } }
    );
    
    results = await resultsResponse.json();
    analysisComplete = results.data.attributes.status === 'completed';
  }
  
  return results.data.attributes.stats;
}

async function checkIPReputation(ip) {
  const API_KEY = process.env.ABUSEIPDB_API_KEY;
  const url = `https://api.abuseipdb.com/api/v2/check?ipAddress=${ip}&maxAgeInDays=90&verbose`;
  
  const response = await fetch(url, {
    method: 'GET',
    headers: { 'Key': API_KEY, 'Accept': 'application/json' }
  });
  
  const data = await response.json();
  const score = data.data.abuseConfidenceScore;
  
  return {
    ip: ip,
    riskLevel: score >= 75 ? 'high' : score >= 50 ? 'medium' : 'low',
    abuseScore: score,
    totalReports: data.data.totalReports
  };
}

async function checkURLSafety(url) {
  const API_KEY = process.env.GOOGLE_SAFE_BROWSING_KEY;
  const endpoint = `https://safebrowsing.googleapis.com/v4/threatMatches:find?key=${API_KEY}`;
  
  const response = await fetch(endpoint, {
    method: 'POST',
    headers: { 'Content-Type': 'application/json' },
    body: JSON.stringify({
      client: { clientId: "yourcompany", clientVersion: "1.0.0" },
      threatInfo: {
        threatTypes: ["MALWARE", "SOCIAL_ENGINEERING", "UNWANTED_SOFTWARE"],
        platformTypes: ["ANY_PLATFORM"],
        threatEntryTypes: ["URL"],
        threatEntries: [{ url: url }]
      }
    })
  });
  
  const data = await response.json();
  return { url, safe: !data.matches || data.matches.length === 0 };
}

const express = require('express');
const multer = require('multer');
const crypto = require('crypto');

const upload = multer({ storage: multer.memoryStorage() });

app.post('/api/secure-upload', upload.single('file'), async (req, res) => {
  const file = req.file;
  const hash = crypto.createHash('sha256').update(file.buffer).digest('hex');
  
  // 1. Check file hash against VirusTotal
  const vtResult = await checkVirusTotalByHash(hash);
  if (vtResult.alreadyScanned && vtResult.malicious > 0) {
    return res.status(400).json({ safe: false, reason: 'Known malware' });
  }
  
  // 2. If unknown, scan with Scanii
  if (!vtResult.alreadyScanned) {
    const scaniiResult = await scanWithScanii(file.buffer, file.originalname);
    if (!scaniiResult.safe) {
      return res.status(400).json({ safe: false, reason: 'Scan failed' });
    }
  }
  
  // 3. Store file securely
  const fileUrl = await storeFile(file, hash);
  res.json({ safe: true, fileUrl });
});

async function ipReputationMiddleware(req, res, next) {
  const clientIP = req.ip || req.connection.remoteAddress;
  const reputation = await checkIPReputation(clientIP);
  
  if (reputation.riskLevel === 'high') {
    return res.status(403).json({ error: 'Access denied: IP flagged' });
  }
  next();
}